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Publications in the context of KFO 262

Fischer K, …, Renner K (P7), Timischl B (CP), Mackensen A (P3), … Kreutz M (P1). Inhibitory effect of tumor cell-derived lactic acid on human T cells. Blood 2007, 109:3812-9.

Moser C, Lang SA  (P6), …, Koehl GE (P1), …, Stoeltzing O. Blocking Hsp90 inhibits the invasive proteries and hepatic growth of human colon cancer cellsand improves the efficacy of oxaliplatin in p53-deficient colon cancer tumors in vivo. Mol Cancer Ther 2007, 6:2868-78.

Stevens AP, Dettmer K (CP), Wallner S, Bosserhoff AK (P2), Oefner PJ (P7). Quantitative analysis of 5’-deoxy-5’-methylthioadenosine in melanoma cells by liquid chromatography-stable isotope ratio tandem mass spectrometry. J Chromatogr B 2008, 879:123-8.

Baumann F, …, Dettmer K (CP), Oefner PJ (P7), …, Kreutz M (P1), …, Bosserhoff AK (P2), Hau P. Lactate promotes glioma migration by TGF-beta2 dependent regulation of matrix metalloproteinase-2  Neuro Oncol 2008, 11:368-80.

Gottfried E, Kreutz M (P1), Mackensen A (P3). Tumor-induced Modulation of dendritic cell function. Cytokine Growth Factor Rev 2008, 19:65-77. Review

Stevens AP, …, Kreutz M (P1), Dettmer K (CP), Oefner PJ (P7), Bosserhoff AK (P2). Direct and tumor microenvironment mediated influences of 5’-deoxy-5’-(methylthio)adenosine on tumor progression of malignant melanoma. J Cell Biochem 2009, 106:210-219.

Lang SA  (P6), …, Hellerbrand C (P5), …, Stoeltzing O (P6). Targeting heat-shock protein 90 (Hsp90) improves efficacy of rapamycin in a model of hepatocellular carcinoma in mice. Hepatology 2009, 49:523-32.

Amann T, …, Stoeltzing O (P6), …, Oefner PJ (P7), Kreutz M (P1), Bosserhoff AK (P2), Hellerbrand C (P5). GLUT1 expression is increased in hepatocellular carcinoma and promotes tumorigenesis. Am J Pathol 2009, 174:1544-52

Mori A, …, Lang SA  (P6), …, Kreutz M (P1), …, Stoeltzing O (P6). Up-regulation of Krüppel-like factor 5 (KLF5) expression in human pancreatic cancer involves p38, HIF-1a and cell contact, and is independent of KRAS/Raf/MEK/Erk signalling. Mol Cancer Res 2009, 7:1390-8.

Amann T, …, Bosserhoff AK (P2), Hellerbrand C (P5). Activated hepatic stellate cells promote tumorigenicity of hepatocellular carcinoma. Cancer Sci 2009,100:646-53.

Stevens AP, Dettmer K (CP), …, Hellerbrand C (P5), Bosserhoff AK (P2), Oefner PJ (P7). Quantification of intermediates of the methionine and polyamine metabolism by liquid chromatography-tandem mass spectrometry in cultured tumor cells and liver biopsies. J Chromatogr A 2010, 1217:3282-3288.

Almstetter MF, …, Spang R (CP), Dettmer K (CP), Oefner PJ (P7). Integrative normalization and comparative analysis for metabolic fingerprinting by comprehensive two-dimensional gas chromatography-time-of-flight mass spectrometry. Anal Chem 2009, 81:5731-9.

Eberhart K, …, Hellerbrand C (P5), Kreutz M (P1), …, Oefner PJ (P7).Low doses of 2-deoxy-glucose sensitize acute lymphoblastic leukemia cells to glucocorticoid-induced apoptosis. Leukemia 2009, 23:2167-70.

Anchang B, …, Oefner PJ (P7), Spang R (CP). Modeling the temporal interplay of molecular signaling and gene expression by using dynamic nested effects models. Proc Natl Acad Sci U S A 2009, 106: 6447-52.

Amann T, …, Dettmer K (CP), …, Oefner PJ (P7), …, Bosserhoff AK (P2), Hellerbrand C (P5). Reduced expression of fibroblast growth factor receptor 2IIIb in hepatocellular carcinoma induces a more aggressive growth. Am J Pathol 2010, 176:1433-1442.

Hackl C, Lang SA  (P6), …, Hellerbrand C (P5), …, Stoeltzing O (P6).Activating transcription factor-3 (ATF3) functions as a tumor suppressor in colon cancer and is up-regulated upon heat-shock protein 90 (Hsp90) inhibition. BMC Cancer 2010, 10:668.

Lang SA, Hackl C, Moser C, Fichtner-Feigl S, Koehl G, Schlitt HJ, Geissler EK, Stoeltzing O. Implication of MTORC2/RICTOR in the MTOR inhibitor-mediated induction of insulin-like growth factor-I receptor (IGF-IR) and human epidermal growth factor receptor-2 (Her2) expression in gastrointestinal cancer cells. Biochim Biophys Acta. 2010 Apr;1803(4):435-42

Singer K,…, Mackensen A (P3), Kreutz M (P1). Warburg phenotype in renal cell carcinoma: High expression of glucose-transporter 1 (GLUT-1) correlates with low CD8+ T-cell infiltrate in the tumor. Int J Cancer 2010, Epub ahead of print on July 6.  

Dietl K, …, Dettmer K (CP), …, Hellerbrand C (P5), …, Oefner PJ (P7), …, Kreutz M (P1). Lactic acid and acidification inhibit TNF secretion and glycolysis of human monocytes. J Immunol 2010, 184: 1200-9.

Kirovski G, …, Kreutz M (P1), …, Bosserhoff AK (P2), Oefner PJ (P7), Hellerbrand C (P5). Downregulation of methylthioadenosine phosphorylase (MTAP) induces progression of hepatocellular carcinoma via accumulation of 5′-deoxy-5′-MTA. Am J Pathol 2011, 178 (3):1145-1152

Amann T, …, Bosserhoff AK (P2), Hellerbrand C (P5). Analysis of a promoter polymorphism of the GLUT1 gene in patients with hepatocellular carcinoma. Mol Membr Biol 2011, Mol Membr Biol. Apr;28(3):182-6.

Singer K, Gottfried E, Kreutz M (P1), Mackensen A (P3). Suppression of T-cell responses by tumor metabolites. Cancer Immunol Immunother 2011, 60:425-31 (Review)

Landfried K, Zhu W, Waldhier MC, Schulz U, Ammer J, Holler B, Wolff D, Edinger M, Peter K, Kreutz M (P1), Andreesen R, Oefner PJ (P7), , Holler E.Tryptophan catabolism is associated with acute GvHD following human allogeneic stem cell transplantation and indicates activation of indole-amine-2,3-dioxygenase. Blood 2011 Dec 22;118(26):6971-4

Taeger J, Moser C, Hellerbrand C (P5), Mycielska ME, Glockzin G, Schlitt HJ, Geissler EK, Stoeltzing O, Lang SA  (P6). Targeting FGFR/PDGFR/VEGFR impairs tumor growth, angiogenesis and metastasisby effects on tumor cells, endothelial cells and pericytes in pancreatic cancer. Mol Cancer Ther.  2011, Nov;10(11):2157-67.

ZhuW, Axel P. Stevens AP, Dettmer K (CP), Gottfried E (P1), Hoves S, Kreutz M (P1), Holler E, Canelas AB, Kema I, Oefner PJ (P7), Quantitative profiling of tryptophan metabolites in serum, urine and cell culture supernatants by liquid chromatography-tandem mass spectrometry, Anal Bioanal Chem 2011, 401(10):3249-61.

Waldhier MC, Almstetter MF, Nurnberger N, Gruber MA, Dettmer K (CP), Oefner PJ (P7), Improved enantiomer resolution and quantification of free d-amino acids in serum and urine by comprehensive two-dimensional gas chromatography-time-of-flight mass spectrometry. J Chromatogr A 2011, 1218 (28):4537-4544

Wachsmuth CJ, Almstetter MF, Waldhier MC, Gruber MA, Nurnberger N, Oefner PJ (P7), Dettmer K (CP), Performance evaluation of gas chromatography-atmospheric pressure chemical ionization-time-of-flight mass spectrometry for metabolic fingerprinting and profiling. Anal Chem 2011, 83 (19): 7514-7522

Dettmer K (CP), Nurnberger N, Kaspar H, Gruber MA, Almstetter MF, Oefner PJ (P7), Metabolite extraction from adherently growing mammalian cells for metabolomics studies: Optimization of harvesting and extraction protocols. Anal Bioanal Chem 2011, 399 (3):1127-1139

Almstetter MF, Appel IJ, Dettmer K (CP), Gruber MA, Oefner PJ (P7). Comparison of two algorithmic data processing strategies for metabolic fingerprinting by comprehensive two-dimensional gas chromatography-time-of-flight mass spectrometry. J Chromatogr 2011,  A 1218 (39):7031-7038

Kohl SM, Klein MS, Oefner PJ (P7), Spang R (CP), Gronwald W (CP). State-of-the art data normalization methods improve NMR-Based metabolomic Analysis. Metabolomics  2011, 8(1):146-160.

Mendler AN, Hu B, Prinz PU, Kreutz M (P1), Gottfried E, Noessner E .Tumor lactic acidosis suppresses CTL function by inhibition of p38 and JNK/c-Jun activation. Int J Cancer 2011, Sep 2.;131(3):633-40. 

Moser C, Lang SA  (P6), Hackl C, Zhang H, Lundgren K, Hong V, McKenzie A, Weber B, Park JS, Schlitt HJ, Geissler EK, Jung YD, Stoeltzing O. Oncogenic MST1R Activity in Pancreatic and Gastric Cancer Represents a Valid Target of HSP90 Inhibitors. Anticancer Res. 2012 Feb;32(2):427-37.

Gottfried E (P1), Kreutz M (P1), Mackensen A (P3). Tumor metabolism as modulator of immune response and tumor progression. Seminars in Cancer Biology, Aug;22(4):335-41 (Review)

Almstetter MF, Oefner PJ (P7), Dettmer K (CP). Comprehensive two-dimensional gas chromatography in metabolomics studies. Anal Bioanal Chem 2012, 402:1993–2013

Moser C, Ruemmele P, Gehmert S, Schenk H, Kreutz M (P1), Mycielska ME, Hackl C, Kroemer A, Schnitzbauer AA, Stoeltzing O, Schlitt HJ, Geissler EK, Lang SA (P6). STAT5b as molecular target in pancreatic cancer–inhibition of tumor growth, angiogenesis, and metastases. Neoplasia. 2012 Oct;14(10):915-25

Ullrich E, Bosch J, Aigner M, Voelkl S, Kroeger I, Hoffmann P, Kreutz M (P1), Dudziak D, Gerbitz A. Advances in cellular therapy: 6th international symposium on the clinical use of cellular products, March 24 and 25, 2011, Erlangen, Germany. Cancer Immunol Immunother. Mar;61(3):433-43.

Moser C, Lang SA, Hackl C, Wagner C, Scheiffert E, Schlitt HJ, Geissler EK, Stoeltzing O. Targeting HSP90 by the Novel Inhibitor NVP-AUY922Reduces Growth and Angiogenesis of Pancreatic Cancer. Anticancer Res. 2012 Jul;32(7):2551-61.

Lang SA, Moser C, Gehmert S, Pfister K, Hackl C, Schnitzbauer AA, Stroszczynski C, Schlitt HJ, Geissler EK, Jung EM. Contrast-enhance ultrasound (CEUS) detects effects of vascular disrupting therapy in an experimental model of gastric cancer. Clin Hemorheol Microcirc. 2012 Dec 27. [Epub ahead of print]

Limm K, Ott C, Wallner S, Mueller DW, Oefner P, Hellerbrand C, Bosserhoff AK (P2). Deregulation of protein methylation in melanoma. Eur J Cancer. 2012 Dec 19. doi:pii: S0959-8049(12)00922-7. 10.1016/j.ejca.2012.11.026. [Epub ahead of print]

Hochrein J, Klein MS, Zacharias HU, Li J, Wijffels G, Schirra HJ, Spang R, Oefner PJ & Gronwald W (CP). Performance Evaluation of Algorithms for the Classification of Metabolic 1H-NMR Fingerprints. Journal of Proteome Research, 2012, 11(12):6242-6251.

Chirasani SR, Leukel P, Gottfried E, Hochrein J, Stadler K, Neumann B, Oefner PJ (P7)Gronwald W (CP), Bogdahn U, Hau P, Kreutz M* (P1), Grauer OM*. Diclofenac inhibits lactate formation and efficiently counteracts local immune suppression in a murine glioma model. Int J Cancer. 2013 Feb 15;132(4):843-53. *M.K. and O.M.G. contributed equally to this work

Klein MS, Oefner PJ & Gronwald W (CP). MetaboQuant: A Tool Combining Individual Peak Calibration and Outlier Detection for Accurate Metabolite Quantification in 1D 1H and 1H-13C HSQC NMR Spectra. Biotechniques, accepted.

Gottfried E, Lang SA, Renner K, Bosserhoff A, Gronwald W, Rehli M, Einhell S, Gedig I, Singer K, Seilbeck A, Mackensen A, Grauer O, Hau P, Dettmer K, Andreesen R, Oefner PJ, Kreutz M. New Aspects of an Old Drug – Diclofenac Targets MYC and Glucose Metabolism in Tumor Cells. PLoS One. 2013 Jul 9;8(7):e66987. doi: 10.1371/journal.pone.0066987. Print 2013.

Dettmer K, Vogl FC, Ritter AP, Zhu W, Nürnberger N, Kreutz M, Oefner PJ, Gronwald W, Gottfried E. Distinct metabolic differences between various human cancer and primary cells. Electrophoresis. 2013 Jul 16. doi: 10.1002/elps.201300228. [Epub ahead of print].